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Question 1 of 3

1. Question
1. Which of the following statements is not true about Chris Lipinski’s ‘‘rule of five’’ used in drug discovery?
- (i) The target molecule should not have more than five hydrogen bond donor atoms/centres
- (ii) The target molecule should not have more than ten hydrogen bond acceptor atoms/centres
- (iii) For linear target molecules, the molecular weight should not be less than 500 Da
- (iv) logP should be less than 5, where ‘P’ refers to the partition coefficient of the candidate molecule
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Question 2 of 3

2. Question
2. Which of the following sequences are generally followed in drug discovery processes?
- (i) Target identification and validation > Compound screening > Lead identification and optimisation > Hit validation
- (ii) Target identification and validation > Compound screening > Hit validation > Lead identification and optimisation
- (iii) Target identification and validation > Lead identification and optimisation > Hit validation > Compound screening
- (iv) Compound screening > Target identification and validation > Hit validation > Lead identification and optimisation
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Question 3 of 3

3. Question
3. How does CRISPR technology assist in drug discovery and development?
- (i) CRISPR/Cas-based high-throughput functional genomic screens help to identify genes can serve as therapeutic targets
- (ii) It helps to produce mutated animal models and cell lines that closely mimic the mutations involved in the disease under consideration
- (iii) It helps to gene develop therapies in diseases such as cancer and HIV
- (iv) All of the above
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